Research: Dysregulation of Host Signaling

Toxoplasma secretes over 1000 effectors into its host cell during infection, resulting in a complex reprogramming of that cell; approximately 20% of mammalian genes show altered transcript levels upon Toxoplasma infection. This creates a novel signaling environment in which infected cells respond to signals differently from bystander cells. We are working to identify the effectors that mediate these differences and their mechanisms of action. In addition, we are working to determine how these remodeled signaling networks can alter the outcome of disease in different hosts.