Reese Lab: Positions Available
- Using single-particle cryo-EM and cellular cryo-ET to determine the atomic order structures of giant protein complexes critical for the function and assembly of the Toxoplasma invasion machinery.
- Combining cell biology with innovative cryo-ET and XL-MS methods to determine structures of parasite complexes required for the biogenesis of the Toxoplasma parasitophorous vacuole.
- Cellular and biophysical studies (cryo-ET, cryo-EM, X-ray crystallography) of signaling complexes essential to parasite invasion of mammalian cells.
- Structure-based drug discovery for inhibitors of kinases essential to the apicomplexan lytic cycle (that is, the parasites that cause the human diseases toxoplasmosis, malaria, and cryptosporidiosis).
This would be a great opportunity for someone with graduate training in molecular cellular biology or genetics to learn to integrate biophysics and biochemistry into their research. Those with strong biophysics training who would like to dive into work on an atypical model organism with strong medical relevance are also encouraged to apply. Applicants should hold a recent Ph.D. (or be within a year of receiving their Ph.D.). If interested, please send a CV with cover letter and contact information for 2-3 references to Michael.Reese@UTSouthwestern.edu
Members of the Reese lab have full access to outstanding shared facilities as UT Southwestern, including high-field NMR, X-ray crystallography (with regular synchotron access), and world-class cryo-EM. UT Southwestern is highly collaborative institution located in the heart of Dallas, TX. Dallas is a diverse city that is fun and affordable, with great food and arts.